Tanım
Interleukin 10, also known as cytokine synthesis inhibitory factor (CSIF), is the founding member of the alpha helical cytokine family, which also includes IL-19, IL-20, IL-22, and IL-24.IL-10 is secreted by a variety of activated hematopoietic cell types as well as by hepatic stellate, keratinocyte-forming, and placenta cell trophoblasts. Mature mouse IL-10 shares 85% amino acid sequence identity with rat, and 70-77% amino acid sequence identity with bovine, canine, equine, feline, human, sheep, and porcine IL-10. Human IL-10 is active on mouse cells, whereas mouse IL-10 does not act on human cells. IL-10 is a key molecule in the control of viral infections and allergies and autoimmune inflammation. It promotes phagocytic uptake and Th2 responses, but inhibits antigen presentation and Th1 pro-inflammatory responses.
This product is available as Fluids, high activity, high purity, low endotoxin, NO labeling.
Product Properties
|
Synonyms |
IL10; IL-10; IL10A; IL-10MGC126451; interleukin 10; interleukin-10; TGIF |
|
Species |
Mouse |
|
Source |
HEK293 Ceslls |
|
Sequence |
Ser19-Ser178 |
|
Accession |
P10168 |
|
Tag |
NO |
|
Predicted molecularmass |
18.8 KDa |
|
Endotoxin |
<0.010 EU per 1 μg of the protein by the LAL method |
|
Purity |
> 95%, determined by SDS-PAGE |
|
Activity |
Measured in a cell proliferation assay using MC/92 mouse mast cells. The EC50 for this effect is 0.10.6 ng/mL. |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Appearance |
Fluids |
Shipping and Storage
-85~-65℃ storage, valid for 1 year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃.
Cautions
1. For your safety and health, please wear lab coat and disposable gloves.
2. This product is for scientific research purposes only.
Ödeme ve Güvenlik
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Sorgu
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