Tanım
Interleukin 12, also known as natural killer cell stimulating factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a heterodimeric pleiotropic cytokine consisting of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit.IL-12 is produced by macrophages and B-lymphocytes, and has been shown to have a variety of effects on T-cells and natural killer (NK) cells. IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and natural killer (NK) cells. These IL-12 activities include induction of IFN-γ and TNF in resting and activated T cells and NK cells; enhancement of the cytotoxic activity of resting NK and T cells, stimulation of resting T cell proliferation in the presence of commensal progenitors; and enhancement of NK cell proliferation.IL-12 is a key mediator of cellular immunity and induces differentiation of Th1 cells from precursor T helper cells. Mouse IL-12 is active on both human and mouse cells, whereas human IL-12 is No active on murine cells.
IL-12 is a heterodimeric cytokine consisting of p35 and p40 subunits. This product is supplied as Liquid, high activity, high purity, low endotoxin, No labeling.
Product Properties
|
Synonyms |
IL12; IL-12; IL-12, subunit p35; IL12A; interleukin 12, p35; cytotoxic lymphocytematuration factor 1, p35) |
|
Species |
Mouse |
|
Source |
HEK293 Ceslls |
|
Sequence |
p40 (Met23-Ser335) & p35 (Arg23-Ala215) |
|
Accession |
P43432 (p40) & P43431 (p35) |
|
Tag |
No |
|
Predicted molecularmass |
59.9 kDa |
|
Endotoxin |
<0.010 EU per 1 μg of the protein by the LAL method |
|
Purity |
> 95%, determined by SDS-PAGE |
|
Activity |
Measured in a cell proliferation assay using PHA-activated mouse splenocytes.The EC50 for this effect is 0.5-4 pg/mL. |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Appearance |
Liquid |
Shipping and Storage
-85~-65℃ storage, valid for 1 year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃.
Cautions
1. For your safety and health, please wear lab coat and disposable gloves.
2. This product is for scientific research purposes only.
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