説明
Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa. Human TNF RII contains four cysteine-rich repeats in its ECD, which shares 58% and 56% amino acid sequence identity with the mouse and rat orthologs, respectively. Those receptors that lack DDs, like TNF RII, bind TNF Receptor-associated Factors, which transduce signals generated by activation of these receptors. Polymorphisms of the human TNFR2 gene, which result in increased expression of both membrane-bound and soluble TNF RII, have been associated with several autoimmune diseases including Crohn’s disease, systemic lupus erythematosus, and familial rheumatoid arthritis.
Specifications
|
Synonyms |
CD120b; Etanercept; p75TBPII; p75TNFR; TNF RII; TNF-R2; TNF-R75; TNFR80; TNFRSF1B; TNFR2; TBPII; TNFBR; TNFR1B |
|
Uniprot No. |
P20333-1 |
|
Source |
Recombinant Biotinylated Human TNFR2/CD120b/TNFRSF1B Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Leu23-Asp257. |
|
Molecular Weight |
The protein has a predicted MW of 26.2 kDa. Due to glycosylation, the protein migrates to 40-60 kDa based on Tris-Bis PAGE result. |
|
Physical Appearance |
Liquid Solution |
|
Purity |
> 95% as determined by SDS-PAGE and HPLC |
|
Endotoxin |
< 1.0 EU per 1μg of the protein by the LAL method. |
|
Formulation |
Supplied as 0.22μm filtered solution in PBS (pH 7.4). |
Storage
The products are shipped with ice pack and can be stored at -80°C for 1 year.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please do not repeated freeze-thaw cycles.
Note
1. For your safety and health, please wear lab coats and disposable gloves for operation.
2. For research use only!
Product Data.
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