説明
CD124 is a type I transmembrane protein. It can regulate the production of IgE antibodies by B cells by binding to interleukin-4 and interleukin-13, and promote the differentiation of Th2 cells by binding to interleukin-4. Studies have shown that IL-4/IL-4R signaling pathway not only plays an important role in the immune system, but also IL-4R is overexpressed in many epithelial tumor cells. IL-4/IL-4R signaling pathway plays a strong role in promoting the survival, proliferation, migration and invasion of epithelial tumors.
Specifications
|
Synonyms |
IL4R；CD124；IL4RA |
|
Uniprot No. |
P24394 |
|
Source |
Recombinant Human IL-4RA Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Met26-His232. |
|
Molecular Weight |
The protein has a predicted MW of 25.67 kDa. And it migrates as 25-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
|
Purity |
> 95% as determined by SDS-PAGE. |
|
Endotoxin |
<0.1 EU per 1μg of the protein by the LAL method. |
|
Formulation |
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). |
|
Reconstitution |
Centrifuge tubes before opening. Dissolve lyophilized protein with sterile PBS to ensure the concentration is greater than 100 ug/mL. |
Storage
The product should be stored at -25~-15℃ for 1 year from the date of receipt.
2-7 days, 2 ~8 °C under sterile conditions after reconstitution.
3 months, -25~-15℃ under sterile conditions after reconstitution.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
Note
1.Please operate with lab coats and disposable gloves for your safety.
2.This product is for research use only.
Product Data.
支払いとセキュリティ
お支払い情報は安全に処理されます。 クレジットカードの詳細を保存したり、クレジットカード情報にアクセスすることはありません
問い合わせ
あなたも好きかもしれません
よくある質問
この製品は研究目的のみに使用され、人間や動物の治療や診断に使用することを意図したものではありません。製品とコンテンツは、
特定のアプリケーションでは、追加のサードパーティの知的財産権が必要になる場合があります。