Beschrijving
The interleukin 17 (IL-17) family of proteins consists of six members (IL-17A through IL-17F) that are secreted structurally related proteins with a conserved cystine knot fold near the C-terminus but considerable sequence variation at the N-terminus.IL-17F is the ligand for IL17RA and IL17RC.The heterodimer formed by IL17A and IL17F is the ligand for the heterodimer complex formed by IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in stimulating the production of other cytokines (e.g., IL6, IL8, and CSF2) and regulating cartilage matrix turnover.
Product Properties
|
Synonyms |
Cytokine ML-1; IL17F; IL-17F; IL24; IL-24; CANDF6; IL-17F; ML1 |
|
Species |
Human |
|
Source |
HEK293 |
|
Sequence |
Arg31-Gln163 |
|
Accession |
Q96PD4 |
|
Tag |
C-His |
|
Molecular Weight |
The protein has a predicted MW of 15.7 kDa. Due to glycosylation, the protein migrates to 23-28 kDa based on Bis-Tris PAGE result. |
|
Endotoxin |
< 1 EU/μg by the LAL method. |
|
Purity |
> 95% as determined by Bis-Tris PAGE; |
|
Activity |
ELISA Data: Immobilized Human IL-17F, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Human IL-17 R alpha, hFc Tag with the EC50 of 0.63 μg/ml determined by ELISA. |
|
Formulation |
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
|
Appearance |
Lyophilized powder |
Shipping and Storage
-25 ~ -15 ° C storage, 1 year expiration date after receipt. After re-solution, store at 2 ~8 °C, 7 days expiration date. After re-dissolution, store at -85~-65°C, 3 months expiration date.
Compounding method
Centrifuge before opening the lid. Use distilled water to reconstitute lyophilized proteins at reconstitution concentrations greater than 100 μg/mL. it is recommended that proteins be portioned out for each experimental dosage upon first use to avoid repeated freeze-thawing.
Cautions
1. For your safety and health, please wear lab coat and disposable gloves.
2. This product is for scientific research purposes only.
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