Beschrijving
IL-33 , a 30 kDa pro-inflammatory protein.IL-33 is constitutively expressed in smooth muscle and airway epithelium. It is upregulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes after IL-1 alpha or IL-1 beta stimulation. The C-terminal fragment of mature IL-33 binds and triggers signaling through mast cell IL-1 R4/ST2L, an orphan receptor chronically involved in augmenting Th2 cell responses. Subsequently, IL-33 and ST2L bind to IL-1R AcP to form a ternary signaling complex. In vitro stimulation of Th2 polarized lymphocytes with mature IL-33 induces IL-5 and IL-13 secretion. In vivo administration of mature IL-33 promotes increased production of IL-5, IL-13, IgE and IgA, as well as splenomegaly and inflammatory infiltration of mucosal tissues. Full-length and mature human IL-33 shares 52-58% amino acid sequence identity with mouse and rat IL-33.
This product is available as Fluids, high activity, high purity, low endotoxin, NO labeling.
Product Properties
|
Synonyms |
IL33; IL-33; interleukin 33; Interleukin-1 family member 11; interleukin -33 |
|
Species |
Human |
|
Source |
HEK293 Ceslls Ceslls |
|
Sequence |
Ser112-Thr270 |
|
Accession |
O95760.1 |
|
Tag |
NO |
|
Predicted molecularmass |
18.0 kDa |
|
Endotoxin |
<0.010 EU per 1 μg of the protein by the LAL method |
|
Purity |
> 95%, determined by SDS-PAGE |
|
Activity |
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells.The EC50 for this effect is 0.05-0.20 ng/mL |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Appearance |
Fluids |
Shipping and Storage
-85~-65℃ storage, valid for 1 year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃.
Cautions
1. For your safety and health, please wear lab coat and disposable gloves.
2. This product is for scientific research purposes only.
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FAQ
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