Beschrijving
IL-1 α and IL-1 β are potent pro-inflammatory cytokines that induce multiple biological activities in different cell types. Two different types of IL-1 receptors have been identified and cloned from human and mouse cells. IL-1 receptor type I is an 80 kDa transmembrane protein with a demonstrated IL-1 signaling function, while IL-1 receptor type II is a 68 kDa membrane protein with a relatively short cytoplasmic tail and no signaling function. The type II receptor acts as a decoy target for IL-1, inhibiting IL-1 activity by preventing IL-1 from binding to the type I receptor.The soluble version of the type II receptor is induced by anti-inflammatory agents (e.g., glucocorticoids, IL-4, and IL-13).
This product is available as Liquid, high activity, high purity, low endotoxin, No labeling.
Product Properties
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Synonyms |
IL1 alpha; IL-1 alpha; IL1; IL1A; IL-1A; IL1-ALPHA; IL1F1; IL-1F1; IL1F1hematopoietin-1; interleukin 1, alpha; interleukin-1 alpha; LAF; LEM; preinterleukin 1 alpha; pro-interleukin-1-alpha |
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Species |
Mouse |
|
Source |
HEK293 Ceslls |
|
Sequence |
Ser6-Ser161 |
|
Accession |
P01582 |
|
Tag |
No |
|
Predicted molecularmass |
18.0 KDa |
|
Endotoxin |
<0.010 EU per 1 μg of the protein by the LAL method |
|
Purity |
> 95%, determined by SDS-PAGE |
|
Activity |
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The EC50 for this effect is 3-7 pg/mL. |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Appearance |
Liquid |
Shipping and Storage
-85~-65℃ storage, valid for 1 year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃.
Cautions
1. For your safety and health, please wear lab coat and disposable gloves.
2. This product is for scientific research purposes only.
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FAQ
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