Beschrijving
The interleukin 17 (IL-17) family of proteins are immunomodulatory cytokines.IL-17E, also known as IL-25, promotes a Th2-favored immune response. This is in contrast to other IL-17 family members, which promote Th1- and Th17-favored inflammation.IL-25 is an important mediator of allergic reactions and protection against intestinal parasites. Mature mouse IL-25 shares 80% and 91% amino acid sequence identity with human and rat IL-25, respectively. IL-25 acts on a variety of cell types that respond with increased production of Th2 cytokines (e.g., IL-4, IL-5, IL-13) and Th1 and Th17 cytokines (e.g., IFN-γ, IL-12, IL-23, IL-17A, IL-17A, and Th17). 23, IL-17A, IL-17F) production is decreased.
This product is supplied as a liquid with high activity, high purity, low endotoxin, and NO labeling.
Product Properties
|
Synonyms |
IL25; IL-25; interleukin 25; Interleukin-17E; interleukin-25 |
|
Species |
Mouse |
|
Source |
HEK293 Ceslls |
|
Sequence |
Val17-Ala169 |
|
Accession |
Q8VHC9 |
|
Tag |
NO |
|
Predicted molecularmass |
17.5 KDa |
|
Endotoxin |
<0.010 EU per 1 μg of the protein by the LAL method |
|
Purity |
> 95%, determined by SDS-PAGE |
|
Activity |
Measured by its ability to induce CXCL1/GRO alpha secretion in HT29 human colon adenocarcinoma cells. The EC50 for this effect is 0.2-1.0 ng/mL. |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Appearance |
Fluids |
Shipping and Storage
-85~-65℃ storage, valid for 1 year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃.
Cautions
1. For your safety and health, please wear lab coat and disposable gloves.
2. This product is for scientific research purposes only.
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FAQ
Het product is alleen bedoeld voor onderzoeksdoeleinden en is niet bedoeld voor therapeutisch of diagnostisch gebruik bij mensen of dieren. Producten en inhoud worden beschermd door patenten, handelsmerken en auteursrechten die eigendom zijn van
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