Description
MMAE, or monomethyl auristatin E, is a potent cytotoxic agent commonly used in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy. It is an antimitotic agent which inhibits cell division by blocking the polymerization of tubulin.
Specifications
Cat.No. |
31903ES60/31903ES80 |
Size |
100 μg/1 mg |
Source |
Monoclonal anti-MMAE antibody, is produced from a hybridoma which was obtained from a mouse immunized with MMAE. |
Buffer |
1×PBS, pH7.4. |
Type |
Monoclonal Antibody |
Isotype |
IgG1 |
Host |
Mouse |
Concentration |
1 mg/mL |
Purity |
>94% as determined by reduced SDS-PAGE >97% as determined by non-reduced SDS-PAGE > 98% as determined by SEC-HPLC |
Activity |
EC50=6.3 ng/mL by ELISA |
Application |
ELISA |
Storage
This product should be stored at -25~-15℃ for one year, do not freeze.
Notes
- This product is for research use only.
- Please operate with lab coats and disposable gloves, for your safety.
Data
SDS-PAGE
Anti-MMAE mouse mAb on SDS-PAGE under reduced condition. The purity is 94.7%;
Anti-MMAE mouse mAb on SDS-PAGE under non-reduced condition. The purity is 97.6%.
SEC-HPLC
The purity of Anti-MMAE mouse mAb is 98% as determined by SEC-HPLC.
ELISA Data
Dose response curve shows that the EC50 of Anti-MMAE mouse mAb is 6.3 ng/mL.