Description
SN38 is the active metabolite of the chemotherapy drug irinotecan (Camptosar). It is a topoisomerase I inhibitor, prevents the enzyme from properly resealing the DNA strands after they have been unwound, which leads to the accumulation of DNA damage.
Specifications
|
Cat.No. |
31905ES60/31905ES80 |
|
Size |
100 μg/1 mg |
|
Source |
Monoclonal anti-SN38 antibody, is produced from a hybridoma which was obtained from a mouse immunized with SN38. |
|
Buffer |
1×PBS, pH7.4. |
|
Type |
Monoclonal Antibody |
|
Isotype |
IgG1 |
|
Host |
Mouse |
|
Concentration |
1 mg/mL |
|
Purity |
＞95% as determined by reduced SDS-PAGE ＞99% as determined by non-reduced SDS-PAGE > 99% as determined by SEC-HPLC |
|
Activity |
EC50=80.5 ng/mL by ELISA |
|
Application |
ELISA |
Storage
This product should be stored at -25~-15℃ for one year, do not freeze.
Notes
- This product is for research use only.
- Please operate with lab coats and disposable gloves, for your safety.
Data
SDS-PAGE
Anti-SN-38 mouse mAb on SDS-PAGE under reduced condition. The purity is 95.5%；
Anti-SN-38 mouse mAb on SDS-PAGE under non-reduced condition. The purity is 99.2%.
SEC-HPLC
The purity of Anti-SN-38 mouse mAb is 100% as determined by SEC-HPLC.
ELISA Data
Dose response curve shows that the EC50 of Anti-SN-38 mouse mAb is 80.5 ng/mL.
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FAQ
The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
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