Description
Nicotinamide, also known as Vitamin B3, is a non-competitive inhibitor of sirtuins, and its inhibitory effect affects a variety of important regulatory mechanisms in vitro and in vivo. Nicotinamide strongly inhibits yeast SIR2-mediated transcriptional silencing, increases rDNA recombination, and shortens replication lifespan. The yeast enzyme PNC1 converts nicotinamide to nicotinic acid, which activates Sir2 and prevents nicotinamide from telomere inhibition and rDNA silencing. Nicotinamide inhibits the deacetylation of p53 and inhibits the deacetylation of histones H3 and H4. Nicotinamide induces apoptosis in a variety of tumor cells, accompanied by caspase cascade activation.
Nicotinamide has been used in preclinical trials for the treatment of cancer and type 1 diabetes.
Features
Purity≥99%
Standardized production, using factory mass production mode
Specifications
|
Cat.No. |
51402ES03/51402ES08 |
|
Size |
1 g/5 g |
|
Synonym |
Niacinamide, Nicotinic acid amide, Vitamin B3, pyridine-3-carboxamide |
|
Target |
PARP1 |
|
CAS No. |
98-92-0 |
|
Molecular formula |
C6H6N2O |
|
Molecular weight |
122.12 |
|
Appearance |
solid powder |
|
Purity |
≥99% |
|
Solubility |
Soluble in DMSO, ethanol and water |
|
Structure |
 |
Components
|
Components No. |
Name |
51402ES03 |
51402ES08 |
|
51402 |
Nicotinamide |
1 g |
5 g |
Shipping and Storage
The Nicotinamide products should be stored at -15～-25℃ for 2 years. Avoid repeated freeze-thaw cycles.
Documents:
Safety Data Sheet
Manuals
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
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