Description
DAPT (GSI-IX) is a novel γ-secretase (γ-secretase) inhibitor that inhibits the production of total Aβ and Aβ42 in cells, which in turn affects cell signaling and cell differentiation. DAPT reduces the total Aβ yield in HEK 293 cells, with an IC50 of 20 nM in HEK 293 cells. DAPT inhibits the production of Aβ and Aβ42 in human neurocytes respectively with IC50 of 115 nM and 200 nM, which are 5-10-fold lower than those when applied to HEK 293 cells.
DAPT inhibits SK-MES-1 cell proliferation in a concentration-dependent manner with an IC50 of 11.265 μM. In addition, DAPT acts on lung squamous cell carcinoma cells and induces apoptosis-dependent and non-dependent apoptosis by inhibiting the Notch receptor signaling pathway. DAPT reduces lymphoid tissue proliferation in CBA-lprg mice and autoimmunity in MRL-lprr mice, and also exhibits resistance for several months in vivo, so DAPT has the potential to be an effective candidate in clinical trials for ALPS and lupus erythematosus (SLE).
Features
Purity≥98%
Standardized production, using factory mass production mode
Specifications
|
Cat.No. |
52104ES10/52104ES50 |
|
Size |
10 mg/50 mg |
|
Synonym |
DAPT; LY374973; GSIIX |
|
CAS No. |
208255-80-5 |
|
Molecular formula |
C23H26F2N2O4 |
|
Molecular weight |
432.46 |
|
Appearance |
solid powder |
|
Purity |
≥98% |
|
Solubility |
Soluble in DMSO (20 mg/mL) |
|
Structure |
 |
Components
|
Components No. |
Name |
52104ES10 |
52104ES50 |
|
52104 |
DAPT |
10 mg |
50 mg |
Shipping and Storage
The DAPT products should be stored at -15～-25℃ for 2 years. Avoid repeated freeze-thaw cycles.
Documents:
Safety Data Sheet
Manuals
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FAQ
The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
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