Description
MG132 is a potent, reversible, cell-permeable proteasome inhibitor (IC50=100 nM), more than 1000-fold more potent than ZLLal in inhibiting the ZLLL-MCA degradation activity of the 20S proteasome. MG132 also inhibits the cell cycle and calpain required for cyclin degradation (IC50=1.2 μM), and induces neurite outgrowth in PC12 cells. In addition, MG132 inhibited IκBα degradation, thereby inhibiting NF-κB pathway activation. MG132 induces apoptosis of MPM cells with the activation of caspase 3/7/8/9 proteins. In addition to inducing apoptosis, MG132 also induced changes in mitochondrial membrane potential and increased intracellular ROS levels.
Features
Purity≥96%
Standardized production, using factory mass production mode
Specifications
|
Cat.No. |
52801ES08/52801ES10/52801ES25/52801ES50/52801ES60 |
|
Size |
5 mg/10 mg/25 mg/50 mg/100 mg |
|
Synonym |
N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide; Z-Leu-Leu-Leu-al; Z-Leu-Leu-Leu-CHO |
|
Target |
Proteasome |
|
CAS No. |
133407-82-6 |
|
Molecular formula |
C26H41N3O5 |
|
Molecular weight |
475.6 |
|
Appearance |
solid powder |
|
Purity |
≥96% |
|
Solubility |
Soluble in DMSO |
|
Structure |
 |
Components
|
Components No. |
Name |
52801ES08 |
52801ES10 |
52801ES25 |
52801ES50 |
52801ES60 |
|
52801 |
MG132 (MG-132) |
5 mg |
10 mg |
25 mg |
50 mg |
100 mg |
Shipping and Storage
The MG132 (MG-132) products should be stored at -15～-25℃ for 2 years. Avoid repeated freeze-thaw cycles.
Documents:
Safety Data Sheet
Manuals
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
Inquiry
You may also like
FAQ
The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
Certain applications may require additional third-party intellectual property rights.
Yeasen is dedicated to ethical science, believing our research should address critical questions while ensuring safety and ethical standards.