Description
Doxycycline Hyclate, is a syntheic oxytetracycline broad-spectrum antibiotic, primarily targeting bacteria responsible for respiratory infections, including Mycoplasma pneumoniae and Haemophilus influenza. Additionally, it can be used to treat variety of infections such as Lyme disease, Rickettsia, and some spirochetes, and has antigenic and insect repellent functions.
Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Doxycycline Hyclate is also an inhibitor of matrix metalloproteinases (MMP), including MMP-8 (neutrophil collagenase; IC50: 30 μM) and MMP-1 (interstitial collagenase; IC50: 300 µM). Doxycycline Hyclate has been observed to significantly decrease the levels and activity of metalloproteinase-9 (MMP-9) in corneal erosion studies. Doxycycline Hyclate blocks collagen activity and increases smooth muscle cell adhesion, and changes the reorganization of fibrillar collagen matrices and cell migration in smooth muscle studies.
Doxycycline hydrochloride is also commonly used in tet-on (rtTA dependent) and tet-off (tTA dependent) systems to regulate gene expression, both in vivo and in vitro.
For other antibiotics, please refer to the related topic of Antibiotic User Manual.
Features
Potency (Anhydrous)：800-920 μg/mg
Standardized production, using factory mass production mode
Applications
Cell culture
Used to treat variety of infections
Specifications
|
CAS NO. |
24390-14-5 |
|
Molecular Fomular |
C22H24N2O8·HCl·0.5H2O·0.5C2H6O |
|
Molecular Weight |
512.94 g/mol |
|
Appearance |
Light yellow powder |
|
Potency (Anhydrous) |
800-920 μg/mg |
|
Solubility |
Soluble in water |
|
Structure |
|
Components
|
Components No. |
Name |
60204ES03 |
60204ES08 |
60204ES25 |
|
60204 |
Doxycycline Hyclate |
1 g |
5 g |
25 g |
Shipping and Storage
The Doxycycline Hyclate products be stored at 2～8℃ for 2 years. The aqueous solution can only be stored stably at 2～8℃ for 5 days, and can be stored at for a longer term at -25～-15℃.
Documents:
Safety Data Sheet
Manuals
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