Description
Cefotaxime sodium salt is a semi synthetic third-generation cephalosporin antibiotic / antibacterial agent. It combines with penicillin binding proteins (PBPs) to prevent the conversion of peptides in the last step of peptidoglycan synthesis, inhibit the synthesis of peptidoglycan, affect the normal synthesis of bacterial cell wall, and finally make the bacteria cleave under the action of autolytic enzymes.
Cefotaxime is a broad-spectrum antibiotic, which significantly affects most Gram-negative bacteria other than Pseudomonas and most gram-positive cocci excluding enterococci. Compared with the first generation, the second generation cephalosporins showed stronger biological activity against Enterobacteriaceae. It can also act on some aminoglycoside resistant antibiotics, including gram-negative bacilli of amikacin. It can also act on penicillin resistant Streptococcus pneumoniae. It can also cooperate with penicillin or aminoglycoside antibiotics to selectively kill Gram-negative bacteria. The stability of lactamase can significantly inhibit the occurrence of bacterial drug resistance.
Cefotaxime does not have plant cytotoxicity, so it is also commonly used in Agrobacterium tumefaciens mediated transformation experiments to control bacterial growth. It can also be used in combination with vancomycin (Cat#60213ES). The commonly used effective concentration is 50-500 mg/L.
For other antibiotics, please refer to the related topic of Antibiotic User Manual.
Features
Activity≥916 μg/mg
Standardized production, using factory mass production mode
Applications
Affects most Gram-negative bacteria other than Pseudomonas and most gram-positive cocci excluding enterococci
Commonly used in Agrobacterium tumefaciens mediated transformation experiments to control bacterial growth
Specifications
|
CAS NO. |
64485-93-4 |
|
Molecular Fomular |
C16H16N5NaO7S2 |
|
Molecular Weight |
477.45 g/mol |
|
Appearance |
White to pale yellow crystalline powder |
|
Activity |
≥916 μg/mg |
|
Solubility |
Dissolve in water (50 mg/mL), Almost insoluble in organic solvents |
|
Structure |
|
Components
|
Components No. |
Name |
60226ES03 |
60226ES08 |
60226ES25 |
60226ES60 |
|
60226 |
Cefotaxime Sodium Salt |
1 g |
5 g |
25 g |
100 g |
Shipping and Storage
The Cefotaxime Sodium Salt products be stored at 2～8℃ for 2 years.
Documents:
Safety Data Sheet
Manuals
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