Description
Interleukin 5 (IL-5) is a member of the hematopoietic Th2 cytokine family and consists of 115 amino acids. Unlike other members of the cytokine family (IL-3 and GM-CSF), this glycoprotein is activated as a homologous dimer. IL-5 is secreted by Th2 cells and mast cells. Its biological activity on B cells and other cell types suggests that IL-5 is functionally important for Th2 cell activity. By binding to its receptor, IL-5 stimulates B cell growth and enhances immunoglobulin secretion. It is also a key factor in the activation of eosinophils. IL-5 has been associated with a variety of diseases, including allergic rhinitis and asthma, with substantial increases seen in circulating tissue, tracheal tissue, and a decrease in sputum eosinophils.
Product Properties
|
Synonyms |
TRF,Interleukin-5 |
|
Uniprot No. |
P05113-1 |
|
Source |
Recombinant Human IL-5 Protein is expressed from HEK293 Cells with His tag at the N-terminal and Fc tag at the C-terminal. It contains Ile20-Ser134. |
|
Molecular Weight |
The protein has a predicted MW of 45.33 kDa. |
|
Purity |
> 95% as determined by SDS-PAGE. |
|
Endotoxin |
<0.1 EU per 1μg of the protein by the LAL method. |
|
Formulation |
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). |
|
Reconstitution |
Centrifuge tubes before opening. The concentration of protein solution used for lyophilization is generally 1mg/mL. Dissolve lyophilized protein with sterile water to ensure the concentration is greater than 100 ug/mL. |
Shipping and Storage
The product should be stored at -25~-15℃ for 1 year from date of receipt.
2-7 days, 2 ~8 °C under sterile conditions after reconstitution.
3 months, -25~-15℃ under sterile conditions after reconstitution.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
Cautions
1.Please operate with lab coats and disposable gloves,for your safety.
2.This product is for research use only.
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
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