Description
Product Information
|
Product Name |
Cat# |
Size |
|
Recombinant Human GM-CSF Protein |
91102ES08 |
5 μg |
|
91102ES50 |
50 μg |
|
|
91102ES60 |
100 μg |
|
|
91102ES76 |
500 μg |
|
|
91102ES80 |
1 mg |
Product Description
GM-CSF (Granulocyte Crop Colony Stimulating Factor) is a cytokine that belongs to the family of colony-stimulating factors. It plays an important role in immune regulation, hematopoiesis, and inflammatory processes. GM-CSF is mainly produced by various cells, including macrophages, T cells, B cells, and fibroblasts. It can stimulate the proliferation, differentiation, and functional activation of granulocytes and monocytes in the hematopoietic cell series. GM-CSF can promote the differentiation of pluripotent stem cells into granulocytes and monocytes in the bone marrow, increase the number of white blood cells, and enhance their function, thereby enhancing the body's immune response and anti infection ability. In addition, GM-CSF plays an important regulatory role in the activation and antimicrobial activity of macrophages and dendritic cells. In clinical practice, GM-CSF is widely used to treat complications related to bone marrow transplantation, malignant tumors, and immune deficiencies. It is also used as a tool in laboratory research to explore the regulatory mechanisms of hematopoietic and immune systems, as well as to develop new therapeutic strategies.
This recombinant human GM-CSF is provided in freeze-dried powder form, with high activity, high purity, low endotoxin, and no additional labels.
Product Properties
|
Synonyms |
Granulocyte/Macrophage Colony-Stimulating Factor, GM-CSF, CSF-2, MGI-1GM, |
|
Source |
E.coli-derived human GM-CSF protein, Ala18-Glu144. |
|
Accession |
|
|
Molecular Weight |
Approximately 14.5 kDa. |
|
AA Sequence |
APARSPSPST QPWEHVNAIQ EARRLLNLSR DTAAEMNETV EVISEMFDLQEPTCLQTRLE LYKQGLRGSL TKLKGPLTMM ASHYKQHCPP TPETSCATQI ITFESFKENL KDFLLVIPFD CWEPVQE |
|
Endotoxin |
< 1.0 EU/μg by the LAL method. |
|
Purity |
> 98%，SDS-PAGE and HPLC detection |
|
Biological Activity |
The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.1 ng/mL, corresponding to a specific activity of > 1.0 × 107 IU/mg. Fully biologically active when compared to standard. |
|
Formulation |
Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4. |
|
Tag |
No Tag |
|
Physical Appearance |
White freeze-dried powder |
Storage
The product should be stored at -25~-15℃ for 1 year from date of receipt.
2-7 days, 2 ~8 °C under sterile conditions after reconstitution.
3-6 months, -85~-65℃ under sterile conditions after reconstitution.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Notes
1. Please operate with lab coats and disposable gloves,for your safety.
2. This product is for research use only.
Documents:
Safety Data Sheet
Manuals
91102_Manual_Ver.EN20240708.pdf
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
Certain applications may require additional third-party intellectual property rights.
Yeasen is dedicated to ethical science, believing our research should address critical questions while ensuring safety and ethical standards.