Description
Hepatocyte Growth Factor(HGF), also known as Scatter Factor and Hepatopoietin A, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases. It is a multidomain molecule that includes an N-terminal PAN/APPLE-like domain, four Kringle domains, and a serine proteinase-like domain that has no detectable protease activity (1 - 5). Mouse HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. It is cleaved after the fourth Kringle domain by a serine protease to form bioactive disulfide-linked HGF with a 60 kDa alpha and 30 kDa beta chain.
Specification
|
Synonyms |
F-TCF; hepatocyte growth factor (hepapoietin A; scatter factor); Hepatopoeitin-A; Hepatopoietin A; |
|
Uniprot No. |
P08048 |
|
Source |
Human HGF Protein is expressed from HEK293 without tag. It contains Gln33-Arg495 (alpha)&Vla496-Leu728(beta). |
|
Molecular Weight |
The protein has a predicted 79.3 kDa |
|
Purity |
> 95% as determined by SDS-PAGE. |
|
Biological Activity |
Measured in a cell proliferation assay using mIMCD-3 mouse epithelial cells. The EC50 for this effect is 1-10 ng/mL. |
|
Endotoxin |
< 0.01 EU per 1 μg of the protein by the LAL method. |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Concentration |
0.2 mg/ml |
Storage
The product should be stored at -85~-65℃ for 1 year from date of receipt.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
Caution
1.Please operate with lab coats and disposable gloves,for your safety.
2.This product is for research use only.
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
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