Description
CD5, also known as Leu-1, Ly-1, and T1, is a 67 kDa transmembrane glycoprotein in the scavenger receptor superfamily. CD5 has been shown to interact homophilically, with CD72 on B cells, and with beta-glucan components of fungal cell walls. CD5 expression on developing thymocytes is positively regulated by signaling through the T cell antigen receptor (TCR) and is upregulated on tolerized peripheral CD4+ cells. It inhibits TCR signaling and promotes T cell nonresponsiveness and survival. CD5 signaling inhibits the generation of regulatory T cells but promotes the development of Th17 cells. Within the B cell lineage, CD5 is expressed on B-1a cells, anergic B cells, and IL-10 producing regulatory B cells. CD5 is also involved in the cellular entry of hepatitis C virus into T cells.
Specifications
|
Synonyms |
CD5 molecule; CD5; LEU1; T1; CD5 antigen |
|
Uniprot No. |
F6V5Q9 |
|
Source |
Recombinant Biotinylated Rhesus macaque CD5 Protein is expressed from HEK293 Cells with His tag and Avi tag at the C-terminal. It contains Arg25-Pro375. |
|
Molecular Weight |
The protein has a predicted MW of 41.7 kDa. Due to glycosylation, the protein migrates to 55-60 kDa based on Tris-Bis PAGE result. |
|
Physical Appearance |
Liquid Solution |
|
Purity |
> 95% as determined by SDS-PAGE and HPLC |
|
Endotoxin |
< 1.0 EU per 1 μg of the protein by the LAL method. |
|
Formulation |
Supplied as 0.22 μm filtered solution in PBS (pH 7.4). |
Storage
The products are shipped with ice pack and can be stored at -80°C for 1 year.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please do not repeated freeze-thaw cycles.
Note
1.For your safety and health, please wear lab coats and disposable gloves for operation.
2.For research use only!
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
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