Description
Her3(Human epidermal growth factor Receptor 3), belongs to the protein kinase superfamily, the tyr protein kinase family, and the EGF receptor subfamily. This membrane-bound glycoprotein has a neuregulin-binding domain but no active kinase domain. It does not mediate intracellular signal transduction through protein phosphorylation, but can form heterodimerers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to generate receptor complexes and initiate pathways that lead to cell proliferation or differentiation.
Specifications
|
Synonyms |
ErbB3; ErbB-3; HER3; HER3c-erbB-3; LCCS2; MDA-BF-1; MGC88033; ERBB3 |
|
Uniprot No. |
P21860 |
|
Source |
Recombinant Human HER3 Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Ser20-Thr643. |
|
Molecular Weight |
The protein has a predicted MW of 70.6 kDa. And it migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
|
Purity |
> 95% as determined by SDS-PAGE. |
|
Concentration |
1mg/mL |
|
Endotoxin |
<0.01 EU per 1μg of the protein by the LAL method. |
|
Formulation |
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). |
Storage
The product should be stored at -25~-15℃ for 1 year from date of receipt.
2-7 days, 2 ~8 °C under sterile conditions after reconstitution.
3 months, -25~-15℃ under sterile conditions after reconstitution.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
Note
1.Please operate with lab coats and disposable gloves,for your safety.
2.This product is for research use only.
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
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