Description
Interleukin 6 receptor (IL-6R), also known as CD126 (cluster of differentiation 126), is a type I cytokine receptor. IL6Ra is part of the IL-6R. Low concentrations of the soluble form of the IL-6 receptor (SIL-6R) act as agonists for IL-6 activity. Dysregulation of IL6 and this receptor has been implicated in the pathogenesis of many diseases such as multiple myeloma, autoimmune diseases and prostate cancer. Furthermore, high levels of IL-6 and SIL-6R have been reported in several chronic inflammatory and autoimmune diseases, as well as in cancer.
Specifications
|
Synonyms |
IL6R,CD126,IL-6R-1,IL-6RA,IL6RA,IL-6R-alpha,IL6RQ,gp80 |
|
Uniprot No. |
P08887 |
|
Source |
Recombinant Human IL-6RA Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Leu 20 - Pro 365. |
|
Molecular Weight |
The protein has a predicted MW of 39.4 kDa. And it migrates as 55-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
|
Purity |
> 95% as determined by SDS-PAGE. |
|
Endotoxin |
<1.0 EU per 1μg of the protein by the LAL method. |
|
Formulation |
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). |
|
Reconstitution |
Centrifuge tubes before opening.The concentration of protein solution used for lyophilization is generally 1mg/mL. Dissolve lyophilized protein with sterile water to ensure the concentration is greater than 100 μg/mL. |
Storage
The product should be stored at -25~-15℃ for 1 year from date of receipt.
2-7 days, 2 ~8 °C under sterile conditions after reconstitution.
3 months, -25~-15℃ under sterile conditions after reconstitution.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
Note
1.Please operate with lab coats and disposable gloves,for your safety.
2.This product is for research use only.
Product Data
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
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