Beskrivning
Interleukin 6 receptor (IL-6R), also known as CD126 (cluster of differentiation 126), is a type I cytokine receptor. IL6Ra is part of the IL-6R. Low concentrations of the soluble form of the IL-6 receptor (SIL-6R) act as agonists for IL-6 activity. Dysregulation of IL6 and this receptor has been implicated in the pathogenesis of many diseases such as multiple myeloma, autoimmune diseases and prostate cancer. Furthermore, high levels of IL-6 and SIL-6R have been reported in several chronic inflammatory and autoimmune diseases, as well as in cancer.
Specifications
|
Synonyms |
IL6R,CD126,IL-6R-1,IL-6RA,IL6RA,IL-6R-alpha,IL6RQ,gp80 |
|
Uniprot No. |
P08887 |
|
Source |
Recombinant Human IL-6RA Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Leu 20 - Pro 365. |
|
Molecular Weight |
The protein has a predicted MW of 39.4 kDa. And it migrates as 55-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
|
Purity |
> 95% as determined by SDS-PAGE. |
|
Endotoxin |
<1.0 EU per 1μg of the protein by the LAL method. |
|
Formulation |
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). |
|
Reconstitution |
Centrifuge tubes before opening.The concentration of protein solution used for lyophilization is generally 1mg/mL. Dissolve lyophilized protein with sterile water to ensure the concentration is greater than 100 μg/mL. |
Storage
The product should be stored at -25~-15℃ for 1 year from date of receipt.
2-7 days, 2 ~8 °C under sterile conditions after reconstitution.
3 months, -25~-15℃ under sterile conditions after reconstitution.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
Note
1.Please operate with lab coats and disposable gloves,for your safety.
2.This product is for research use only.
Product Data
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Förfrågan
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