描述
IL-33 , a 30 kDa pro-inflammatory protein.IL-33 is constitutively expressed in smooth muscle and airway epithelium. It is upregulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes after IL-1 alpha or IL-1 beta stimulation. The C-terminal fragment of mature IL-33 binds and triggers signaling through mast cell IL-1 R4/ST2L, an orphan receptor chronically involved in augmenting Th2 cell responses. Subsequently, IL-33 and ST2L bind to IL-1R AcP to form a ternary signaling complex. In vitro stimulation of Th2 polarized lymphocytes with mature IL-33 induces IL-5 and IL-13 secretion. In vivo administration of mature IL-33 promotes increased production of IL-5, IL-13, IgE and IgA, as well as splenomegaly and inflammatory infiltration of mucosal tissues. Full-length and mature human IL-33 shares 52-58% amino acid sequence identity with mouse and rat IL-33.
This product is available as Fluids, high activity, high purity, low endotoxin, NO labeling.
Product Properties
|
Synonyms |
IL33; IL-33; interleukin 33; Interleukin-1 family member 11; interleukin -33 |
|
Species |
Human |
|
Source |
HEK293 Ceslls Ceslls |
|
Sequence |
Ser112-Thr270 |
|
Accession |
O95760.1 |
|
Tag |
NO |
|
Predicted molecularmass |
18.0 kDa |
|
Endotoxin |
<0.010 EU per 1 μg of the protein by the LAL method |
|
Purity |
> 95%, determined by SDS-PAGE |
|
Activity |
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells.The EC50 for this effect is 0.05-0.20 ng/mL |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Appearance |
Fluids |
Shipping and Storage
-85~-65℃ storage, valid for 1 year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃.
Cautions
1. For your safety and health, please wear lab coat and disposable gloves.
2. This product is for scientific research purposes only.
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
Certain applications may require additional third-party intellectual property rights.
Yeasen is dedicated to ethical science, believing our research should address critical questions while ensuring safety and ethical standards.