描述
IL-1 refers to two pleiotropic cytokines, IL-1 α (IL-1F1) and IL-1 β (IL-1F2), which are the products of different genes.IL-1 α and IL-1 β are structurally related polypeptides that are approximately 17% identical in amino acids (aa) in mice. Both proteins are produced by a variety of cells in response to inflammatory factors, infection, or microbial endotoxins. Although IL-1 alpha and IL-1 beta are independently regulated, they bind to the same receptor and perform the same biological role. IL-1 RI binds directly to either IL-1 alpha or IL-1 beta, and then binds to the IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex capable of signaling. IL-1 RII has a high affinity for IL-1 beta but acts as a decoy receptor and a negative regulator of IL-1 beta activity.
This product is supplied as a liquid, high activity, high purity, low endotoxin, and label free.
Product Properties
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Synonyms |
IL1 beta; IL-1 beta; IL-1; IL1B; IL-1b; IL1-BETA; IL-1F2; IL1F2IL-1 beta; interleukin 1, beta; interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta |
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Species |
Mouse |
|
Source |
HEK293 Ceslls |
|
Sequence |
Val118-Ser269 |
|
Accession |
P10749 |
|
Tag |
No |
|
Predicted molecularmass |
17.4 KDa |
|
Endotoxin |
<0.010 EU per 1 μg of the protein by the LAL method |
|
Purity |
> 95%, determined by SDS-PAGE |
|
Activity |
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The EC50 for this effect is 2-10 pg/mL. |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Appearance |
Liquid |
Shipping and Storage
-85~-65℃ storage, valid for 1 year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃.
Cautions
1. For your safety and health, please wear lab coat and disposable gloves.
2. This product is for scientific research purposes only.
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
Certain applications may require additional third-party intellectual property rights.
Yeasen is dedicated to ethical science, believing our research should address critical questions while ensuring safety and ethical standards.