描述
IL-1 α and IL-1 β are potent pro-inflammatory cytokines that induce multiple biological activities in different cell types. Two different types of IL-1 receptors have been identified and cloned from human and mouse cells. IL-1 receptor type I is an 80 kDa transmembrane protein with a demonstrated IL-1 signaling function, while IL-1 receptor type II is a 68 kDa membrane protein with a relatively short cytoplasmic tail and no signaling function. The type II receptor acts as a decoy target for IL-1, inhibiting IL-1 activity by preventing IL-1 from binding to the type I receptor.The soluble version of the type II receptor is induced by anti-inflammatory agents (e.g., glucocorticoids, IL-4, and IL-13).
This product is available as Liquid, high activity, high purity, low endotoxin, No labeling.
Product Properties
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Synonyms |
IL1 alpha; IL-1 alpha; IL1; IL1A; IL-1A; IL1-ALPHA; IL1F1; IL-1F1; IL1F1hematopoietin-1; interleukin 1, alpha; interleukin-1 alpha; LAF; LEM; preinterleukin 1 alpha; pro-interleukin-1-alpha |
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Species |
Mouse |
|
Source |
HEK293 Ceslls |
|
Sequence |
Ser6-Ser161 |
|
Accession |
P01582 |
|
Tag |
No |
|
Predicted molecularmass |
18.0 KDa |
|
Endotoxin |
<0.010 EU per 1 μg of the protein by the LAL method |
|
Purity |
> 95%, determined by SDS-PAGE |
|
Activity |
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The EC50 for this effect is 3-7 pg/mL. |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Appearance |
Liquid |
Shipping and Storage
-85~-65℃ storage, valid for 1 year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃.
Cautions
1. For your safety and health, please wear lab coat and disposable gloves.
2. This product is for scientific research purposes only.
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
Certain applications may require additional third-party intellectual property rights.
Yeasen is dedicated to ethical science, believing our research should address critical questions while ensuring safety and ethical standards.