描述
Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that stimulates the proliferation and differentiation of pluripotent hematopoietic stem cells, as well as various lineage-directed progenitor cells. In addition, IL-3 affects the functional activity of mature mast cells, basophils, eosinophils and macrophages. Due to its diverse functions and targets, it was initially studied under different names, including mast cell growth factor P-cell stimulating factor, burst-promoting activity, multicolony stimulating factor, thy-1 inducing factor, and WEHI-3 growth factor. In addition to activated T cells, other cell types such as human thymic epithelial cells, activated mouse mast cells, mouse keratinocytes, and neuronal/astrocytes also produce IL-3.At the amino acid sequence level, mature human and mouse IL-3 share only 29% sequence identity.
This product is supplied as a liquid with high activity, high purity, low endotoxin, and No labeling.
Product Properties
|
Synonyms |
IL3; IL-3; IL-3MGC79398; interleukin 3 (colony-stimulating factor, multiple); interleukin-3; Mast cell growth factor; mast-cell growth factor; MCGF; |
|
Species |
Mouse |
|
Source |
HEK293 Ceslls |
|
Sequence |
Asp33-Cys166 |
|
Accession |
P01586 |
|
Tag |
No |
|
Predicted molecularmass |
15.1 KDa |
|
Endotoxin |
<0.010 EU per 1 μg of the protein by the LAL method |
|
Purity |
> 95%, determined by SDS-PAGE |
|
Activity |
Measured in a cell proliferation assay using NFS60 mouse myelogenous leukemia lymphoblast cells.The EC50 for this effect is 20-100 pg/mL. |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Appearance |
Liquid |
Shipping and Storage
-85~-65℃ storage, valid for one year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the bottle. It is recommended to aliquot once for experimental use and freeze at -80℃ after aliquoting.
Cautions
1. For your safety and health, please wear lab coat and disposable gloves.
2. This product is for scientific research purposes only.
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
Certain applications may require additional third-party intellectual property rights.
Yeasen is dedicated to ethical science, believing our research should address critical questions while ensuring safety and ethical standards.