描述
Interleukin 10, also known as cytokine synthesis inhibitory factor (CSIF), is the founding member of the alpha helical cytokine family, which also includes IL-19, IL-20, IL-22, and IL-24.IL-10 is secreted by a variety of activated hematopoietic cell types as well as by hepatic stellate, keratinocyte-forming, and placenta cell trophoblasts. Mature mouse IL-10 shares 85% amino acid sequence identity with rat, and 70-77% amino acid sequence identity with bovine, canine, equine, feline, human, sheep, and porcine IL-10. Human IL-10 is active on mouse cells, whereas mouse IL-10 does not act on human cells. IL-10 is a key molecule in the control of viral infections and allergies and autoimmune inflammation. It promotes phagocytic uptake and Th2 responses, but inhibits antigen presentation and Th1 pro-inflammatory responses.
This product is available as Fluids, high activity, high purity, low endotoxin, NO labeling.
Product Properties
|
Synonyms |
IL10; IL-10; IL10A; IL-10MGC126451; interleukin 10; interleukin-10; TGIF |
|
Species |
Mouse |
|
Source |
HEK293 Ceslls |
|
Sequence |
Ser19-Ser178 |
|
Accession |
P10168 |
|
Tag |
NO |
|
Predicted molecularmass |
18.8 KDa |
|
Endotoxin |
<0.010 EU per 1 μg of the protein by the LAL method |
|
Purity |
> 95%, determined by SDS-PAGE |
|
Activity |
Measured in a cell proliferation assay using MC/92 mouse mast cells. The EC50 for this effect is 0.10.6 ng/mL. |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Appearance |
Fluids |
Shipping and Storage
-85~-65℃ storage, valid for 1 year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃.
Cautions
1. For your safety and health, please wear lab coat and disposable gloves.
2. This product is for scientific research purposes only.
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
Certain applications may require additional third-party intellectual property rights.
Yeasen is dedicated to ethical science, believing our research should address critical questions while ensuring safety and ethical standards.