描述
Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28 - 40 kDa type I transmembrane glycoprotein.SCF promotes the survival, differentiation, and mobilization of a wide range of cell types including myeloid, erythroid, megakaryocyte, lymphoid, germline, and melanocyte progenitors.SCF is the a major growth and activation factor for mast cells and eosinophils. Mouse SCF shares 93% amino acid sequence identity with rat SCF and 72% - 75% amino acid sequence identity with canine, feline and human SCF. Rat SCF is active in mouse and human cells, but human SCF is only weakly active in mouse cells. Non-covalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF R/c-kit to trigger receptor dimerization and signaling.
This product is available as Liquid, high activity, high purity, low endotoxin, No labeling.
Product Properties
|
Synonyms |
SCF; SCFStem cell factor; SFc-Kit ligand; SHEP7; SLF; steel factor |
|
Species |
Mouse |
|
Source |
HEK293 Ceslls |
|
Sequence |
Lys26-Ala189 |
|
Accession |
P20826 |
|
Tag |
No |
|
Predicted molecularmass |
18.3 KDa |
|
Endotoxin |
<0.010 EU per 1 μg of the protein by the LAL method |
|
Purity |
> 95%, determined by SDS-PAGE |
|
Activity |
Measured in a cell proliferation assay using TF1 human erythroleukemic cells. The EC50 for this effect is 2.5-10 ng/mL. |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Appearance |
Liquid |
Shipping and Storage
-85~-65℃ storage, valid for 1 year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃.
Cautions
1. For your safety and health, please wear lab coat and disposable gloves.
2. This product is for scientific research purposes only.
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
Certain applications may require additional third-party intellectual property rights.
Yeasen is dedicated to ethical science, believing our research should address critical questions while ensuring safety and ethical standards.