描述
Interleukin-12 (IL-12) is a potent regulator of cell-mediated immune responses, inducing the production of IFN-γ by NK and T cells.IL12 is produced by activated monocytes/macrophages, B-lymphocytes, and connective tissue-type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+, and CD8+ cells and induces the development of IFN-γ-producing Th1 cells.
Recombinant Human IL-12 is a disulfide-linked p35 subunit and p40 subunit. This Recombinant Human IL-12 is supplied as a lyophilized powder with high activity, high purity, low endotoxin, and no redundant labeling.
Specification
|
Synonyms |
IL12; p70; Interleukin-12, NKSF, CTL Maturation Factor (TCMF), Cytotoxic Lymphocyte Maturation Factor (CLMF), TSF |
|
Species |
Human |
|
Source |
CHO Cells |
|
Sequence |
Recombinant human IL-12 is composed of P40(Ile23-Ser328) and |
|
Accession |
P29460(IL12P40), P29459(IL12P35) |
|
Tag |
Not |
|
Molecular Weight |
Predicted molecular |
|
Endotoxin |
≤10 EU/mg by the LAL method |
|
Purity |
≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining) |
|
Activity |
Measured by its ability to induce Interferon gamma secretion by human natural |
|
Formulation |
Lyophilized from a 0.22 μm-filtered solution containing PBS, 5% mannitol |
|
Appearance |
Lyophilized powder |
Storage
-25 ~ -15 ° C storage, from the date of receipt of goods, the expiration date of 1 year. After re-solution, store at 2 ~8 °C, 7-10 days expiration date. After re-dissolution, -85 ~ -65 ° C storage, 6 months expiration date.
Compounding Methods
Use sterile deionized water to reconstitute freeze-dried proteins. It is recommended that proteins be divided for first use to avoid repeated freeze-thawing.
Cautions
1. Please operate with lab coats and disposable gloves,for your safety.
2. This product is for research use only.
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
Certain applications may require additional third-party intellectual property rights.
Yeasen is dedicated to ethical science, believing our research should address critical questions while ensuring safety and ethical standards.