وصف
Interleukin 12, also known as natural killer cell stimulating factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a heterodimeric pleiotropic cytokine consisting of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit.IL-12 is produced by macrophages and B-lymphocytes, and has been shown to have a variety of effects on T-cells and natural killer (NK) cells. IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and natural killer (NK) cells. These IL-12 activities include induction of IFN-γ and TNF in resting and activated T cells and NK cells; enhancement of the cytotoxic activity of resting NK and T cells, stimulation of resting T cell proliferation in the presence of commensal progenitors; and enhancement of NK cell proliferation.IL-12 is a key mediator of cellular immunity and induces differentiation of Th1 cells from precursor T helper cells. Mouse IL-12 is active on both human and mouse cells, whereas human IL-12 is No active on murine cells.
IL-12 is a heterodimeric cytokine consisting of p35 and p40 subunits. This product is supplied as Liquid, high activity, high purity, low endotoxin, No labeling.
Product Properties
|
Synonyms |
IL12; IL-12; IL-12, subunit p35; IL12A; interleukin 12, p35; cytotoxic lymphocytematuration factor 1, p35) |
|
Species |
Mouse |
|
Source |
HEK293 Ceslls |
|
Sequence |
p40 (Met23-Ser335) & p35 (Arg23-Ala215) |
|
Accession |
P43432 (p40) & P43431 (p35) |
|
Tag |
No |
|
Predicted molecularmass |
59.9 kDa |
|
Endotoxin |
<0.010 EU per 1 μg of the protein by the LAL method |
|
Purity |
> 95%, determined by SDS-PAGE |
|
Activity |
Measured in a cell proliferation assay using PHA-activated mouse splenocytes.The EC50 for this effect is 0.5-4 pg/mL. |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Appearance |
Liquid |
Shipping and Storage
-85~-65℃ storage, valid for 1 year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃.
Cautions
1. For your safety and health, please wear lab coat and disposable gloves.
2. This product is for scientific research purposes only.
الدفع والأمن
تتم معالجة معلومات الدفع الخاصة بك بشكل آمن. لا نقوم بتخزين تفاصيل بطاقة الائتمان ولا يمكننا الوصول إلى معلومات بطاقة الائتمان الخاصة بك.
سؤال
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التعليمات
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