Descripción
IL-1 α and IL-1 β are potent pro-inflammatory cytokines that induce multiple biological activities in different cell types. Two different types of IL-1 receptors have been identified and cloned from human and mouse cells. IL-1 receptor type I is an 80 kDa transmembrane protein with a demonstrated IL-1 signaling function, while IL-1 receptor type II is a 68 kDa membrane protein with a relatively short cytoplasmic tail and no signaling function. The type II receptor acts as a decoy target for IL-1, inhibiting IL-1 activity by preventing IL-1 from binding to the type I receptor.The soluble version of the type II receptor is induced by anti-inflammatory agents (e.g., glucocorticoids, IL-4, and IL-13).
This product is available as Liquid, high activity, high purity, low endotoxin, No labeling.
Product Properties
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Synonyms |
IL1 alpha; IL-1 alpha; IL1; IL1A; IL-1A; IL1-ALPHA; IL1F1; IL-1F1; IL1F1hematopoietin-1; interleukin 1, alpha; interleukin-1 alpha; LAF; LEM; preinterleukin 1 alpha; pro-interleukin-1-alpha |
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Species |
Mouse |
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Source |
HEK293 Ceslls |
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Sequence |
Ser6-Ser161 |
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Accession |
P01582 |
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Tag |
No |
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Predicted molecularmass |
18.0 KDa |
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Endotoxin |
<0.010 EU per 1 μg of the protein by the LAL method |
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Purity |
> 95%, determined by SDS-PAGE |
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Activity |
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The EC50 for this effect is 3-7 pg/mL. |
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Formulation |
Dissolved in sterile PBS buffer. |
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Appearance |
Liquid |
Shipping and Storage
-85~-65℃ storage, valid for 1 year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃.
Cautions
1. For your safety and health, please wear lab coat and disposable gloves.
2. This product is for scientific research purposes only.
Pago y seguridad
Su información de pago se procesa de forma segura. No almacenamos detalles de la tarjeta de crédito ni tenemos acceso a la información de su tarjeta de crédito.
Consulta
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Preguntas frecuentes
El producto es solo para fines de investigación y no está destinado a uso terapéutico o diagnóstico en humanos o animales. Los productos y el contenido están protegidos por patentes, marcas comerciales y derechos de autor propiedad de Yeasen Biotechnology. Los símbolos de marca comercial indican el país de origen, no necesariamente el registro en todas las regiones.
Algunas aplicaciones pueden requerir derechos de propiedad intelectual adicionales de terceros.
Yeasen se dedica a la ciencia ética y cree que nuestra investigación debe abordar cuestiones críticas al tiempo que garantiza la seguridad y los estándares éticos.