Descripción
Interleukin 10, also known as cytokine synthesis inhibitory factor (CSIF), is the founding member of the alpha helical cytokine family, which also includes IL-19, IL-20, IL-22, and IL-24.IL-10 is secreted by a variety of activated hematopoietic cell types as well as by hepatic stellate, keratinocyte-forming, and placenta cell trophoblasts. Mature mouse IL-10 shares 85% amino acid sequence identity with rat, and 70-77% amino acid sequence identity with bovine, canine, equine, feline, human, sheep, and porcine IL-10. Human IL-10 is active on mouse cells, whereas mouse IL-10 does not act on human cells. IL-10 is a key molecule in the control of viral infections and allergies and autoimmune inflammation. It promotes phagocytic uptake and Th2 responses, but inhibits antigen presentation and Th1 pro-inflammatory responses.
This product is available as Fluids, high activity, high purity, low endotoxin, NO labeling.
Product Properties
|
Synonyms |
IL10; IL-10; IL10A; IL-10MGC126451; interleukin 10; interleukin-10; TGIF |
|
Species |
Mouse |
|
Source |
HEK293 Ceslls |
|
Sequence |
Ser19-Ser178 |
|
Accession |
P10168 |
|
Tag |
NO |
|
Predicted molecularmass |
18.8 KDa |
|
Endotoxin |
<0.010 EU per 1 μg of the protein by the LAL method |
|
Purity |
> 95%, determined by SDS-PAGE |
|
Activity |
Measured in a cell proliferation assay using MC/92 mouse mast cells. The EC50 for this effect is 0.10.6 ng/mL. |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Appearance |
Fluids |
Shipping and Storage
-85~-65℃ storage, valid for 1 year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃.
Cautions
1. For your safety and health, please wear lab coat and disposable gloves.
2. This product is for scientific research purposes only.
Pago y seguridad
Su información de pago se procesa de forma segura. No almacenamos detalles de la tarjeta de crédito ni tenemos acceso a la información de su tarjeta de crédito.
Consulta
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Preguntas frecuentes
El producto es solo para fines de investigación y no está destinado a uso terapéutico o diagnóstico en humanos o animales. Los productos y el contenido están protegidos por patentes, marcas comerciales y derechos de autor propiedad de Yeasen Biotechnology. Los símbolos de marca comercial indican el país de origen, no necesariamente el registro en todas las regiones.
Algunas aplicaciones pueden requerir derechos de propiedad intelectual adicionales de terceros.
Yeasen se dedica a la ciencia ética y cree que nuestra investigación debe abordar cuestiones críticas al tiempo que garantiza la seguridad y los estándares éticos.