Descripción
IL-11 (interleukin 11) is a pleiotropic cytokine in the IL-6 family, which also includes LIF, CNTF, oncostatin M, cardiotrophin-1, IL-27, and IL-31. In humans, IL-11 has also been found to be an adipogenesis inhibitory factor (AGIF). The aa sequence identity of IL-11 in mature mice with human, rat and canine IL-11 is 88%, 97% and 89%, respectively.IL-11 is secreted by cell types such as osteoblasts, synoviocytes, fibroblasts, chondrocytes, intestinal myofibroblasts, and trophoblasts . It is predominantly present in plasma during inflammation (e.g., inflammation associated with viral infections, cancer, or inflammatory arthritis) and is thought to have primarily anti-inflammatory effects.IL-11 stimulates hematopoiesis and thrombosis, regulates macrophage differentiation, and provides mucosal protection in the intestinal tract. IL-11 has also been found to enhance T-cell polarization to Th2, promote B-cell IgG production, increase osteoclast bone resorption, protect endothelial cells from oxidative stress, and regulate epithelial proliferation and apoptosis.
This product is available as Liquid, high activity, high purity, low endotoxin, No labeling.
Product Properties
|
Synonyms |
IL11; IL-11; IL-11Oprelvekin; interleukin 11; interleukin-11; Oprelvekin |
|
Species |
Mouse |
|
Source |
HEK293 Ceslls |
|
Sequence |
Gly23-Leu199 |
|
Accession |
P47873 |
|
Tag |
No |
|
Predicted molecularmass |
19.1 KDa |
|
Endotoxin |
<0.010 EU per 1 μg of the protein by the LAL method |
|
Purity |
> 95%, determined by SDS-PAGE |
|
Activity |
Measured in a cell proliferation assay using T11 mouse plasmacytoma cells. The EC50 for this effect is 0.04-0.4 ng/mL. |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Appearance |
Liquid |
Shipping and Storage
-85~-65℃ storage, valid for 1 year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one time experimental use, after aliquoting, -80℃.
Cautions
1. For your safety and health, please wear lab coat and disposable gloves.
2. This product is for scientific research purposes only.
Pago y seguridad
Su información de pago se procesa de forma segura. No almacenamos detalles de la tarjeta de crédito ni tenemos acceso a la información de su tarjeta de crédito.
Consulta
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Preguntas frecuentes
El producto es solo para fines de investigación y no está destinado a uso terapéutico o diagnóstico en humanos o animales. Los productos y el contenido están protegidos por patentes, marcas comerciales y derechos de autor propiedad de Yeasen Biotechnology. Los símbolos de marca comercial indican el país de origen, no necesariamente el registro en todas las regiones.
Algunas aplicaciones pueden requerir derechos de propiedad intelectual adicionales de terceros.
Yeasen se dedica a la ciencia ética y cree que nuestra investigación debe abordar cuestiones críticas al tiempo que garantiza la seguridad y los estándares éticos.