विवरण
|
Cat# |
Size |
|
|
Recombinant Human IGF-1 Protein
|
92211ES10 |
10 μg |
|
92211ES60 |
100 μg |
|
|
92211ES76 |
500 μg |
|
|
92211ES80 |
1 mg |
IGFs are mitogenic peptide growth factors that stimulate the proliferation and survival of a variety of cell types in vitro, including muscle, bone, and cartilage tissues.IGFs are produced primarily by the liver, although a variety of tissues produce IGFs at different times.IGFs belong to the insulin gene family, which also contains insulin and relaxin.IGFs are structurally and functionally similar to insulin but have a much much higher growth-promoting activity.The expression of IGF-II is influenced by placental prolactin, whereas the expression of IGF-I is regulated by growth hormone.Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/mannose-6-phosphate receptor. Mature IGFs are produced by proteolytic processing of inactive precursor proteins that contain N-terminal and C-terminal prepeptide regions.
This product, Recombinant Human IGF-1, is supplied as a lyophilized powder with high activity, high purity and low endotoxin.
Specification
|
Synonyms |
Somatomedin C, IGF-I, IGF-IA, Mechano growth factor, MGF |
|
Source |
E.coli-derived human IL-IGF-1 protein, Gly49-Ala118 without tag. |
|
Accession |
P05019 |
|
Molecular Weight |
Approximately 7.6 kDa. |
|
AA Sequence |
GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA |
|
Endotoxin |
< 0.01 EU/μg by the LAL method. |
|
Purity |
> 97%, SDS-PAGE and HPLC detection |
|
Biological Activity |
Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using serum free human MCF-7 cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 × 105 IU/mg. |
|
Formulation |
Lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.0. |
|
Physical Appearance |
White lyophilized powder |
Storage
-25 ~ -15 ° C storage, valid for 1 year after receipt.
After re-solution, store at 2 ~8 °C, 30 days expiration date. After re-dissolving, store at -85~-65°C, 3 months expiration date.
Compounding Methods
Centrifuge before uncapping to bring contents to the bottom. Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg/mL, which can be diluted even further according to subsequent experiments; for long-term storage, it is recommended that carrier proteins (0.1% BSA) be added to the dilution buffer; dispense for a single experimental dose and freeze at -80°C to avoid repeated freezing and thawing.
Cautions
1.For your safety and health, please wear lab coat and disposable gloves.
2.This product is for scientific research purposes only.
भुगतान और सुरक्षा
आपकी भुगतान जानकारी सुरक्षित रूप से संसाधित की जाती है। हम क्रेडिट कार्ड के विवरण को संग्रहीत नहीं करते हैं और न ही आपके क्रेडिट कार्ड की जानकारी तक पहुंच है।
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उपवास
यह उत्पाद केवल शोध उद्देश्यों के लिए है और मनुष्यों या जानवरों में चिकित्सीय या नैदानिक उपयोग के लिए अभिप्रेत नहीं है। उत्पाद और सामग्री येसेन बायोटेक्नोलॉजी के स्वामित्व वाले पेटेंट, ट्रेडमार्क और कॉपीराइट द्वारा संरक्षित हैं। ट्रेडमार्क प्रतीक मूल देश को इंगित करते हैं, जरूरी नहीं कि सभी क्षेत्रों में पंजीकरण हो।
कुछ अनुप्रयोगों के लिए अतिरिक्त तृतीय-पक्ष बौद्धिक संपदा अधिकारों की आवश्यकता हो सकती है।
येसेन नैतिक विज्ञान के प्रति समर्पित हैं, उनका मानना है कि हमारे शोध में सुरक्षा और नैतिक मानकों को सुनिश्चित करते हुए महत्वपूर्ण प्रश्नों का समाधान किया जाना चाहिए।