IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation, and its effects typically enhance the antigen-specific response of immune cells.The biological effects of IL-21 include: inducing T cell-stimulated B cells to differentiate into plasma cells and memory B cells; combining with IL-4 to stimulate IgG production; and, in the absence of T cell signaling, inducing apoptotic effects in naïve B cells and stimulated B cells to induce apoptotic effects. In addition, IL-21 promotes the antitumor activity of CD8+ T cells and NK cells.IL-21 exerts its effects by binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (γc) found in other cytokine receptors, including IL-2, IL-4, IL-7, IL-9, and IL-15.IL-21/IL -21R interaction triggers a cascade of events, including activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.

This product, Recombinant Human IL-21, is supplied as a lyophilized powder with high activity, high purity and low endotoxin.

Specification

Storage

-25 ~ -15 ° C storage, valid for 1 year after receipt.

After re-solution, store at 2 ~8 °C, 30 days expiration date. After re-dissolving, store at -85~-65°C, 3 months expiration date.

Compounding Methods

Centrifuge before uncapping to bring contents to the bottom. Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg/mL, which can be diluted even further according to subsequent experiments; for long-term storage, it is recommended that carrier proteins (0.1% BSA) be added to the dilution buffer; dispense for a single experimental dose and freeze at -80°C to avoid repeated freezing and thawing. 

Cautions

1. Please operate with lab coats and disposable gloves,for your safety.   

2. This product is for research use only.