描述
Interleukin-23 (IL-23) is a pro-inflammatory heterodimeric protein consisting of two subunits: a unique p19 subunit and a p40 subunit shared with IL-12.IL-23 is secreted by activated dendritic cells and macrophages and signals through the receptor for IL-23R in complex with IL-12Rβ 1. IL-23 has been shown to enhance the proliferation of memory T cells. It also stimulates IFN-γ production in NK cells, induces IL-17 production, and drives Th17-mediated responses.
This Recombinant Human IL-23 is supplied in liquid form, highly active, highly pure, low endotoxin, and label free.
Specification
|
Synonyms |
Interleukin-23；IL23 |
|
Source |
HEK293 |
|
Source |
Human IL-23 p40（Ile23-Ser328）&Human IL-23 p19 (Arg20-Pro189) |
|
Accession |
p40（P29460）& p19（AAG37232） |
|
Molecular Weight |
Predicted Moleucular weight: 36.5 kDa (p40) & 18.5 kDa (p19) |
|
Endotoxin |
< 0.01 EU/μg by the LAL method. |
|
Purity |
> 95%，determined by SDS-PAGE. |
|
Biological Activity |
Measured by its ability to induce IL-17 secretion by mouse splenocytes.The EC50 for this effect is 0.25 pg/mL. |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Tag |
Not |
|
Physical Appearance |
Fluids |
|
concentration |
0.2 mg/mL |
Storage
-85~-65℃ storage, valid for 1 year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃.
Cautions
1. Please operate with lab coats and disposable gloves,for your safety.
2. This product is for research use only.
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本產品僅用於研究目的，不用於人類或動物的治療或診斷用途。產品和內容受以下公司的專利、商標和版權保護：
某些應用程式可能需要額外的第三方智慧財產權。