描述
Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28 - 40 kDa type I transmembrane glycoprotein.SCF promotes the survival, differentiation, and mobilization of a wide range of cell types including myeloid, erythroid, megakaryocyte, lymphoid, germline, and melanocyte progenitors.SCF is the a major growth and activation factor for mast cells and eosinophils. Mouse SCF shares 93% amino acid sequence identity with rat SCF and 72% - 75% amino acid sequence identity with canine, feline and human SCF. Rat SCF is active in mouse and human cells, but human SCF is only weakly active in mouse cells. Non-covalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF R/c-kit to trigger receptor dimerization and signaling.
This product is available as Liquid, high activity, high purity, low endotoxin, No labeling.
Product Properties
|
Synonyms |
SCF; SCFStem cell factor; SFc-Kit ligand; SHEP7; SLF; steel factor |
|
Species |
Mouse |
|
Source |
HEK293 Ceslls |
|
Sequence |
Lys26-Ala189 |
|
Accession |
P20826 |
|
Tag |
No |
|
Predicted molecularmass |
18.3 KDa |
|
Endotoxin |
<0.010 EU per 1 μg of the protein by the LAL method |
|
Purity |
> 95%, determined by SDS-PAGE |
|
Activity |
Measured in a cell proliferation assay using TF1 human erythroleukemic cells. The EC50 for this effect is 2.5-10 ng/mL. |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Appearance |
Liquid |
Shipping and Storage
-85~-65℃ storage, valid for 1 year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃.
Cautions
1. For your safety and health, please wear lab coat and disposable gloves.
2. This product is for scientific research purposes only.
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本產品僅用於研究目的，不用於人類或動物的治療或診斷用途。產品和內容受以下公司的專利、商標和版權保護：
某些應用程式可能需要額外的第三方智慧財產權。