IL-27 (interleukin 27) is a cytokine belonging to the IL-12 family, a heterodimeric cytokine consisting of EBI3 and p28 subunits.IL-27 is produced by activated dendritic cells and macrophages in response to Toll-like receptor ligands and pro-inflammatory cytokines.IL-27 is produced by activated dendritic cells and macrophages in response to Toll-like receptor ligands and pro-inflammatory cytokines.IL-27 is produced through the induction of the expression of the transcription factor T-bet and up-regulation of IL-12Rβ 2 to promote the differentiation of CD4+ T cells into the Th1 lineage, which in turn inhibits the differentiation and proliferation of Th2 and Th17.IL-27 is a member of the recently discovered family of proinflammatory and immunomodulatory cytokines IL-6/IL-12.IL-27 acts by binding to its receptors WSX-1 and gp130, which leads to the activation of the Jak/STAT signaling cascade, suggesting that IL-27 is involved in the regulation of immune processes.

Recombinant Human IL-27 produced by HEK293 cells is a non-disulfide-linked heterodimeric protein consisting of the 209 amino acid-long EBI3 subunit and the 215 amino acid-long IL-27-p28 subunit, with a total sequence length of 424 amino acid residues. This product is available as Fluids, high purity, high activity, low endotoxin, NO labeling.

Product Properties

Shipping and Storage

-85~-65℃ storage, valid for 1 year after receipt.

Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃. 

Cautions

1. For your safety and health, please wear lab coat and disposable gloves.

2. This product is for scientific research purposes only.