Fas, also known as APO1 or CD95, belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. All appear to block the extrinsic apoptosis pathway induced by the Fas ligand (FasL, TNFSF6), a type II transmembrane protein of the TNF family that can be expressed on activated Tlymphocytes, NK cells and cells in immune privileged sites, or shed in soluble form. Engagement of FAS induces oligomerization of preformed Fas trimers. The activated receptor recruits the adaptor molecule FADD to form the DeathInducing Signaling Complex (DISC). Upon activation, caspases in the DISC initiate the apoptotic signaling cascade. Fas is prominent in epithelial cells, hepatocytes, activated mature lymphocytes, virus-transformed lymphocytes and tumor cells. It is an essential mediator in the activationinduced death of T lymphocytes that terminates the immune reaction. In immuneprivileged tissues, infiltrating Fasbearing lymphocytes and inflammatory cells are killed by FasL engagement. Both humans and mice with genetic defects in Fas accumulate abnormal lymphocytes and develop systemic autoimmunity. The Fas pathway also appears to crosscommunicate with the BIM (mitochondrial/intrinsic) apoptosis pathway.

Specifications

Storage

Transported with ice packs. Store at -20℃ to -80℃, valid for one year.

After reconstitution, store unopened at -20 to -80°C for 3 to 6 months. After reconstitution, store at 2 to 8°C for 2 to 7 days.

It is recommended to store in aliquots and freeze for the first use to avoid repeated freezing and thawing.

Note

1. Avoid repeated freezing and thawing.

2. For your safety and health, please wear lab coat and disposable gloves when operating.

3. This product is for scientific research purposes only.

Product Data